Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Return of the chalones.

Laura W Gamer1, John Nove, Vicki Rosen

  • 1Department of Oral and Developmental Biology, Harvard School of Dental Medicine and The Forsyth Institute, Boston, MA 02115, USA.

Developmental Cell
|February 15, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An ex vivo appositional growth model to study periosteal activity and associated BMP signaling.

JBMR plus·2026
Same author

Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting.

Nature communications·2026
Same author

Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification.

bioRxiv : the preprint server for biology·2026
Same author

A closed-loop cell therapy engineered to autonomously secrete Activin A inhibitor protects from fibrodysplasia ossificans progressiva.

bioRxiv : the preprint server for biology·2026
Same author

Not just a pain in the bone.

Science (New York, N.Y.)·2026
Same author

Targeting the Alk4 pathway protects against age-related bone loss.

bioRxiv : the preprint server for biology·2025

Growth and differentiation factors (GDFs), part of the TGFbeta superfamily, may act as chalones. These molecules are suggested to regulate organ size by inhibiting cell growth.

Area of Science:

  • Cell biology
  • Developmental biology
  • Molecular biology

Background:

  • Transforming growth factor-beta (TGFbeta) superfamily members are crucial for embryonic development and tissue maintenance.
  • The precise mechanisms controlling organ size remain incompletely understood.

Purpose of the Study:

  • To investigate the role of growth and differentiation factors (GDFs) in organ size regulation.
  • To explore the potential of GDFs as endogenous negative growth regulators (chalones).

Main Methods:

  • The study focuses on recent work investigating GDFs, a subset of TGFbeta-like molecules.
  • Analysis of existing literature and experimental data on GDF function.

Main Results:

  • Recent findings indicate that GDFs may play a significant role in controlling organ size.

Related Experiment Videos

  • Evidence suggests these GDFs function as chalones, actively inhibiting cell proliferation.

    • Conclusions:

    • Growth and differentiation factors (GDFs) are proposed as key regulators of organ size.
    • GDFs represent potential candidates for the long-sought chalones, offering insights into negative growth control.