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A new trick for Cyclin-Cdk: activation of STAT
Debra L Silver1, Denise J Montell
1Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 Wolfe Street, Baltimore, MD 21205, USA.
Developmental Cell
|February 15, 2003
Abstract
None:
New work in Drosophila demonstrates that cdk4 loss causes phenotypes similar to the loss of JAK/STAT pathway components. Cdk4 overexpression can bypass requirements for JAK but not STAT. These results demonstrate a new function for Cdk4 and a new mode of STAT activation.