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A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle
Yasutomi Kamei1, Junko Mizukami, Shinji Miura
1PRESTO, Japan Science and Technology Corporation, National Institute of Health and Nutrition, 1-23-1, Toyama Shinjuku-ku, Tokyo 162-863, Japan. ykamei@nih.go.jp
Abstract:
Lipoprotein lipase (LPL) plays a role in lipid usage in skeletal muscle by hydrolyzing plasma triglycerides into fatty acids, which are further utilized for beta-oxidation. Lipid usage is stimulated during fasting, diabetes mellitus and exercise, concomitant with enhanced LPL expression in skeletal muscle. Here we show that the forkhead type transcription factor FKHR is strongly induced in skeletal muscle in fasting mice, in mice with streptozotocin-induced diabetes and in mice after treadmill running. Ectopic expression of FKHR enhanced LPL gene expression in C2C12 muscle cells in culture. These results implicate FKHR as an important modulator of lipid metabolism in skeletal muscle.