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Updated: Sep 27, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
Published on: February 17, 2023
Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli
Robert J Fitzhenry1, Mark P Stevens, Claire Jenkins
1Centre for Paediatric Gastroenterology, Lower 3rd Floor, Royal Free Hospital, Pond St, NW3 2QG, London, UK.
Abstract:
Human intestinal in vitro organ culture was used to assess the tissue tropism of human isolates of Escherichia coli O103:H2 and O103:H- that express intimin epsilon. Both strains showed tropism for follicle associated epithelium and limited adhesion to other regions of the small and large intestine. This is similar to the tissue tropism shown by intimin gamma enterohaemorrhagic (EHEC) O157:H7, but distinct from that of intimin alpha enteropathogenic (EPEC) O127:H6.

