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Characterization and role of protozoan parasite proteasomes
André Paugam1, Anne Laure Bulteau, Jean Dupouy-Camet
1Laboratoire Signalisation et Parasites (EA 3623), Université Paris 5, C.H.U. Cochin, 27, rue du Faubourg Saint Jacques 75014 Paris, France. andre.paugam@cch.ap-hop-paris.fr
Trends in Parasitology
|February 15, 2003
Abstract:
The proteasome, a large non-lysosomal multi-subunit protease complex, is ubiquitous in eukaryotic cells. In protozoan parasites, the proteasome is involved in cell differentiation and replication, and could therefore be a promising therapeutic target. This article reviews the present knowledge of proteasomes in protozoan parasites of medical importance such as Giardia, Entamoeba, Leishmania, Trypanosoma, Plasmodium and Toxoplasma spp.