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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

[Quinolones and Streptococcus pneumoniae. Mechanisms of action and resistance]

R Taléns-Visconti1, T M Garrigues, E Cantón

  • 1Unidad de Microbiología Experimental, Centro de Investigación, Hospital Universitario La Fe, Valencia, Spain. rtalens@uv.es

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|February 15, 2003
PubMed

Insights

Streptococcus pneumoniae causes pneumonia and other infections. Understanding fluoroquinolone resistance mechanisms in S. pneumoniae is crucial for effective antibiotic treatment.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Pharmacology

Context:

  • Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and other serious infections.
  • Emergence of antibiotic resistance necessitates the investigation of new antimicrobial agents.
  • Molecular studies have elucidated bacterial resistance mechanisms and genetic exchange.

Purpose:

  • To review the mechanism of action of quinolones.
  • To explore the mechanisms of fluoroquinolone resistance in S. pneumoniae.
  • To highlight the clinical and epidemiological significance of S. pneumoniae resistance.

Summary:

  • Fluoroquinolones target bacterial DNA gyrase and topoisomerase IV.
  • Resistance in S. pneumoniae can involve mutations in gyrase, topoisomerase IV, or both.
  • The specific quinolone structure influences bactericidal activity and treatment outcomes.

Impact:

  • Knowledge of resistance mechanisms guides the selection of appropriate antibiotic therapy.
  • Understanding structure-activity relationships aids in developing new, effective fluoroquinolones.
  • Informed treatment strategies are essential for combating S. pneumoniae infections.

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