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Related Experiment Videos

Risperidone and megacolon.

D K Lim1, R Mahendran

  • 1Department of General Psychiatry, Institute of Mental Health, Woodbridge Hospital, Singapore 539747. dominic.lim@chmeds.ac.nz

Singapore Medical Journal
|February 18, 2003
PubMed
Summary
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This case study reports a rare instance of megacolon in a schizophrenia patient treated with risperidone. The condition improved with reduced dosage, suggesting a potential link between risperidone and gastro-intestinal motility.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gastroenterology

Background:

  • Risperidone, an atypical antipsychotic, antagonizes 5HT2 and D2 dopamine receptors.
  • It is generally considered safe with minimal gastro-intestinal (GI) side effects.
  • Schizophrenia treatment often involves atypical antipsychotics like risperidone.

Observation:

  • A 44-year-old male patient with schizophrenia developed significant abdominal distension after 25 days of risperidone treatment.
  • Diagnostic imaging (X-ray) and colonoscopy confirmed the presence of megacolon.
  • Symptoms resolved after surgical decompression and a reduction in the risperidone dosage.

Findings:

  • The case highlights a potential association between risperidone use and the development of megacolon.

Related Experiment Videos

  • Neuro-electro-physiological mechanisms of GI motility are discussed in relation to this adverse effect.
  • The complication appears to be dose-related.

    • Implications:

    • Clinicians should maintain a heightened awareness of potential GI complications, such as megacolon, when prescribing risperidone.
    • Further research into the dose-dependent effects of risperidone on gastro-intestinal motility is warranted.
    • This finding may inform risk-benefit assessments for risperidone therapy in susceptible individuals.