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Eosinophilia and endomyocardial fibrosis
The American Journal of Cardiology
|March 4, 1976
Summary
A boy with severe eosinophilia developed progressive heart failure. Autopsy revealed endocardial fibrosis, suggesting a link between eosinophilia and heart damage, despite no signs of leukemia.
Area of Science:
- Cardiology
- Hematology
- Pathology
Background:
- A 12-year-old boy presented with progressive heart failure.
- Initial symptoms included marked leukocytosis (white blood cell count 188,500/mm3) with 90% eosinophilia.
Purpose of the Study:
- To investigate the potential link between eosinophilia and the development of endomyocardial fibrosis.
- To understand the etiology of heart failure in a pediatric patient with a history of severe eosinophilia.
Main Methods:
- Case study analysis.
- Clinical and pathological examination of a pediatric patient.
- Autopsy findings.
Main Results:
- Leukocytosis and eosinophilia resolved within 6 months.
- Heart failure progressed over 2.5 years.
- Autopsy revealed severe endocardial fibrosis extending into the myocardium, with no evidence of leukemia.
Conclusions:
- Endomyocardial fibrosis may be associated with prior severe eosinophilia.
- The etiology of endocardial fibrosis in this case is likely related to eosinophilic activity.
- This case highlights a potential, albeit unknown, mechanism linking eosinophilia to cardiac pathology.