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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Diagnostic value of C-reactive protein in patients with angiographically documented coronary heart disease

Esin Eren1, Necat Yilmaz, Sadrettin Pence

  • 1Department of Biochemistry, Gaziantep University Medical School, Gaziantep, Turkey.

Acta Medica (Hradec Kralove)
|February 18, 2003
PubMed

Insights

Serum C-reactive protein (CRP) can help predict coronary artery disease (CAD). While CRP levels were higher in patients with CAD, they did not correlate with disease severity.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry
  • Biomarkers

Background:

  • Coronary artery disease (CAD) poses a significant global health challenge.
  • Accurate diagnostic tools are crucial for early detection and management of CAD.
  • Serum C-reactive protein (CRP) is an inflammatory marker with potential prognostic value.

Purpose of the Study:

  • To assess the diagnostic utility of serum C-reactive protein (CRP) levels in identifying angiographically confirmed coronary artery disease (CAD).
  • To investigate the correlation between CRP levels and the severity of CAD, including the number of diseased vessels and degree of stenosis.

Main Methods:

  • Blood samples were collected from 198 patients with angiographically documented CAD, 85 patients with clinical indications but no CAD, and 41 healthy volunteers.
  • Serum CRP levels were measured 24 hours prior to coronary angiography.
  • CAD severity was quantified by the number of affected vessels and degree of arterial stenosis.

Main Results:

  • CRP levels were significantly elevated in patients with CAD compared to control groups (p<0.05).
  • Receiver Operating Characteristic (ROC) curve analysis indicated a diagnostic value for CRP in predicting CAD, particularly in females (0.659) versus males (0.542).
  • CRP levels did not show a significant association with the number of diseased vessels or the degree of stenosis (p>0.05).
  • Multiple logistic regression identified CRP as an independent risk factor for CAD after adjusting for established risk factors.

Conclusions:

  • Serum CRP measurement demonstrates diagnostic value in predicting the presence of angiographically confirmed CAD.
  • CRP levels are not associated with the degree or severity of coronary artery disease.
  • CRP may serve as a valuable independent biomarker for CAD detection.
Abstract

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