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Updated: Aug 11, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Antiphospholipid antibodies and stroke in Down syndrome
P Gatenby1, R Tucko, C Andrews
1Department of Immunopathology, The Canberra Hospital and the Canberra Clinical School, University of Sydney, Garran, ACT, Australia. paul.gatenby@act.gov.au
Abstract:
Two patients with Down syndrome and the primary antiphospholipid antibody are described. One patient had a vasculopathy similar to that previously described as Moyamoya. Down syndrome is characterized by immune defects including a tendency to autoimmune phenomena. This report extends the scope of these observations and particularly draws out the potential role of antiphospholipid antibodies. Indeed antiphospholipid antibodies may well explain the well-known association of Down syndrome and stroke.
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