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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Antiphospholipid antibodies and stroke in Down syndrome
P Gatenby1, R Tucko, C Andrews
1Department of Immunopathology, The Canberra Hospital and the Canberra Clinical School, University of Sydney, Garran, ACT, Australia. paul.gatenby@act.gov.au
Lupus
|February 18, 2003
Summary
This study describes two patients with Down syndrome and antiphospholipid antibodies, one with Moyamoya-like vasculopathy. Antiphospholipid antibodies may explain the link between Down syndrome and stroke.
Area of Science:
- Neurology
- Immunology
- Genetics
Background:
- Down syndrome is associated with immune defects and autoimmune tendencies.
- Stroke is a known complication in individuals with Down syndrome.
Observation:
- Two patients with Down syndrome and antiphospholipid antibodies were observed.
- One patient presented with a vasculopathy resembling Moyamoya disease.
Findings:
- The presence of antiphospholipid antibodies is highlighted in these cases.
- Antiphospholipid antibodies may be a contributing factor to the observed vasculopathy.
Implications:
- This report suggests antiphospholipid antibodies could explain the association between Down syndrome and stroke.
- Further research into autoimmune phenomena in Down syndrome is warranted.
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