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Related Experiment Videos

Patterning the limb before and after SHH signalling.

Lia Panman1, Rolf Zeller

  • 1Department of Developmental Biology, Utrecht University, Padualaan 8, NL-3584 CH Utrecht, The Netherlands.

Journal of Anatomy
|February 18, 2003
PubMed
Summary
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Vertebrate limb development relies on cell-cell signaling for patterning. New research revises textbook views, showing mesenchymal responsiveness to Sonic hedgehog (SHH) signaling precedes its expression.

Area of Science:

  • Developmental Biology
  • Embryogenesis
  • Molecular Genetics

Background:

  • The vertebrate limb serves as a key model for studying embryonic patterning and organogenesis.
  • Recent advances combine molecular, genetic, and experimental approaches to understand limb bud development.
  • Existing models of limb development require revision based on new findings.

Purpose of the Study:

  • To review current understanding of cell-cell signaling in vertebrate limb development.
  • To discuss mechanisms of limb bud morphogenesis, including long-range and signal relay.
  • To highlight novel findings regarding the establishment of mesenchymal responsiveness to SHH signaling.

Main Methods:

  • Review of recent molecular and genetic studies.
  • Analysis of experimental manipulations in developing limb buds.

Related Experiment Videos

  • Integration of findings on signaling pathways and cellular responses.

    • Main Results:

    • Signaling by the polarizing region is crucial for limb patterning.
    • Limb bud morphogenesis is regulated by complex signaling networks.
    • Differential mesenchymal responsiveness to SHH signaling is established before SHH expression.

    Conclusions:

    • Textbook concepts of vertebrate limb development need updating.
    • Understanding SHH signaling dynamics is key to limb patterning.
    • Limb development involves intricate, coordinated molecular interactions.