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Related Experiment Videos

Digital development and morphogenesis.

J J Sanz-Ezquerro1, C Tickle

  • 1Departamento de Inmunología y Oncología, Centro Nacional de Biotecnología, Cantoblanco UAM, 28049 Madrid, Spain.

Journal of Anatomy
|February 18, 2003
PubMed
Summary
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Signalling interactions involving Sonic hedgehog (SHH) and Fibroblast Growth Factors (FGFs) are crucial for limb development. Digit formation shows plasticity, with anatomy fixed during morphogenesis, and joint/tip formation processes are discussed.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Limb development relies on signaling between the SHH-producing polarizing region and FGF-producing apical ectodermal ridge.
  • The precise mechanisms translating cellular positional information into anatomical structures, particularly digit morphogenesis, remain unclear.
  • Understanding digit formation, including anteroposterior patterning and growth cessation, is essential.

Purpose of the Study:

  • To review recent data on vertebrate digit development.
  • To elucidate the molecular and cellular basis of digit morphogenesis.
  • To discuss the processes of joint generation, segmentation, and digit tip formation.

Main Methods:

  • Review of recent scientific literature on digit development.

Related Experiment Videos

  • Analysis of data from manipulations of morphogenetic signals, including SHH application.
  • Discussion of established knowledge and emerging findings in the field.

    • Main Results:

    • Digit primordia exhibit plasticity, with anatomy becoming irreversibly fixed during morphogenesis.
    • Manipulation of signals like SHH influences digit formation.
    • Key processes in joint formation, segmentation, and digit tip development are highlighted.

    Conclusions:

    • Signaling pathways are critical for limb outgrowth and patterning.
    • Digit development involves a period of plasticity followed by irreversible fixation of anatomy.
    • Further research is needed to fully understand the molecular and cellular underpinnings of digit morphogenesis.