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Calculation of steady-state distribution delay between central and peripheral compartments in two-compartment models
1Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille 11, Marseille, France.
European Journal of Drug Metabolism and Pharmacokinetics
|February 18, 2003
Abstract:
A lag time may exist between blood drug concentration and drug effect. Various factors can contribute to the lag time, among which the drug distribution delay is a significant one. The drug distribution delay can also exist between different compartments. An equation was derived to calculate the steady-state drug concentration delay between central and peripheral compartments in a two-compartment model with infusion regimen.