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Related Experiment Videos

Bicuspid aortic valve associated with aortic dilatation: a community-based study.

Vuyisile T Nkomo1, Maurice Enriquez-Sarano, Naser M Ammash

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|February 18, 2003
PubMed
Summary

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Bicuspid aortic valve (BAV) is linked to aortic dilatation in a community study, even without significant valve dysfunction. This finding highlights BAV as a risk factor for aortic size changes.

Area of Science:

  • Cardiovascular Medicine
  • Genetics and Genomics
  • Radiology and Imaging

Background:

  • Bicuspid aortic valve (BAV) association with aortic dilatation is primarily reported in retrospective and tertiary care settings.
  • Previous studies often involved patients with valvular dysfunction or surgical cases.
  • An independent link between BAV and aortic dilatation in a community-based cohort remained undemonstrated.

Purpose of the Study:

  • To investigate the association between bicuspid aortic valve (BAV) and aortic dilatation within a community population.
  • To determine if BAV independently correlates with aortic size changes.
  • To assess aortic dimensions in individuals with BAV, irrespective of significant valvular dysfunction.

Main Methods:

  • A community-based study in Olmsted County, Minnesota, identified residents with BAV (n=44) and matched controls.

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  • Participants were assessed using transthoracic echocardiography.
  • Aortic measurements, including the aortic anulus, sinus, and ascending aorta, were compared between BAV and control groups.

    • Main Results:

    • Significant differences in aortic dimensions were observed between the BAV and control groups.
    • The BAV group showed larger aortic anulus (P=0.002), aortic sinus (P=0.0001), and proximal ascending aorta (P=0.0001) measurements.
    • These associations persisted after adjusting for hemodynamic factors like blood pressure and valve velocity.

    Conclusions:

    • Bicuspid aortic valve (BAV) is independently associated with altered aortic dimensions in a community setting.
    • This association exists even in the absence of hemodynamically significant aortic valve stenosis or regurgitation.
    • BAV may represent a risk factor for aortic dilatation independent of its direct valvular effects.