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A case of gliosarcoma appearing as ischaemic stroke
S Züchner1, W Kawohl, B Sellhaus
1Department of Neurology, Aachen University Hospital, Aachen, Germany. stephen.zuechner@post.rwth-aachen.de
Journal of Neurology, Neurosurgery, and Psychiatry
|February 18, 2003
Summary
Malignant brain tumors can cause ischemic stroke, a rare occurrence. This case highlights gliosarcoma invading blood vessels as a cause of stroke, emphasizing its importance as a differential diagnosis.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Ischemic stroke secondary to malignant brain tumors is exceptionally rare.
- Diagnostic challenges persist despite advanced imaging like computed tomography (CT) and angiography.
Observation:
- A 46-year-old man presented with stroke symptoms, initially diagnosed as middle cerebral artery (MCA) infarction via CT and angiography.
- Magnetic resonance imaging (MRI), performed under general anesthesia due to claustrophobia, revealed a left temporal gliosarcoma (WHO grade IV).
Findings:
- The gliosarcoma infiltrated the wall of an intracranial blood vessel.
- This vascular invasion by tumor cells is a novel finding in gliosarcoma-associated stroke.
Implications:
- Malignant brain tumors should be considered in the differential diagnosis of ischemic stroke, especially in atypical presentations.
- This case underscores the importance of comprehensive neuroimaging, including MRI, for accurate diagnosis and management of complex neurological conditions.