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Neuroleptic malignant syndrome in Kufs' disease
A Reif1, M F Schneider, A Hoyer
1Department of Psychiatry and Psychotherapy, Julius-Maximilians-University Würzburg, Germany. a.reif@gmx.net
Journal of Neurology, Neurosurgery, and Psychiatry
|February 18, 2003
Abstract:
A patient with adult neuronal ceroid lipofuscinosis (ANCL; Kufs' disease) is described in whom neuroleptic malignant syndrome occurred, initially presenting as catatonic syndrome. Comprehensive neuroimaging studies were conducted including FDG-PET, IBZM-SPECT, and beta-CIT-SPECT, electrophysiological examinations and an ex vivo contracture test exposing muscle biopsy specimens to neuroleptics. Collectively the results argued for an involvement of the muscle in neuroleptic malignant syndrome at least in ANCL.