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Related Experiment Videos

Bone disease after renal transplantation.

James G Heaf1

  • 1Department of Nephrology B, Copenhagen University Hospital in Herlev, Denmark. heaf@dadlnet.dk

Transplantation
|February 18, 2003
PubMed
Summary

Bone disease is a common complication after renal transplantation, leading to fractures and pain. Prophylactic treatments like calcium, vitamin D, and biphosphonates show promise in managing these bone complications.

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Area of Science:

  • Nephrology
  • Orthopedics
  • Endocrinology

Background:

  • Bone disease is a frequent complication following renal transplantation.
  • Key syndromes include bone loss (3% annual fracture rate), hip osteonecrosis, and bone pain.
  • Etiologies encompass pre-existing uremic osteodystrophy, post-transplant glucocorticoids, impaired renal function, and persistent hyperparathyroidism.

Purpose of the Study:

  • To review the common bone diseases after renal transplantation.
  • To discuss the underlying causes and contributing factors.
  • To outline current and emerging prophylactic strategies.

Main Methods:

  • Literature review of bone disease post-renal transplantation.
  • Analysis of causes including uremic osteodystrophy, immunosuppressive therapy, and graft function.
  • Evaluation of prophylactic measures and treatment options.

Main Results:

  • Bone loss is significant, up to 9% in the first year post-transplant.
  • Causes are multifactorial, involving pre-existing conditions and post-operative factors.
  • Prophylactic strategies include nutritional support, hormone therapy, and surgical intervention.

Conclusions:

  • Bone disease is a significant concern after renal transplantation, necessitating proactive management.
  • Preoperative and postoperative interventions are crucial for mitigating bone loss and fractures.
  • Emerging treatments like biphosphonates offer new avenues for prophylaxis, though indications require further definition.

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