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[Synthesis and binding affinity of 3-aryl-7-hydroxycoumarins to human alpha and beta estrogen receptors]
S Kirkiacharian1, A T Lormier, M Resche-Rigon
1Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, 5 rue Jean-Baptiste Clément, F92296-Chatenay Malabry Cedex.
Annales Pharmaceutiques Francaises
|February 18, 2003
Abstract:
The synthesis of a set of substituted 3-aryl-7-hydroxycoumarins was performed. The study of the relations between their structure and their relative binding affinity (RBA) to human alpha and B estrogen receptors was achieved.