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Effect of probiotic Lactobacillus strains in children with atopic dermatitis

Vibeke Rosenfeldt1, Eva Benfeldt, Susanne Dam Nielsen

  • 1Research Department of Human Nutrition and the LMC Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Copenhagen, Denmark.

The Journal of Allergy and Clinical Immunology
|February 18, 2003
PubMed

Insights

Probiotic supplementation with Lactobacillus rhamnosus and Lactobacillus reuteri improved eczema in children with atopic dermatitis (AD). This oral bacteriotherapy showed significant benefits, particularly for allergic patients, reducing eczema extent and inflammation.

Area of Science:

  • Microbiology
  • Immunology
  • Dermatology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • Oral bacteriotherapy using probiotics is being explored for AD management.
  • Probiotics may modulate the immune system and gut microbiota, influencing AD symptoms.

Purpose of the Study:

  • To assess the clinical efficacy of a specific probiotic combination in children with AD.
  • To evaluate the anti-inflammatory effects of probiotic supplementation.
  • To identify patient subgroups that may benefit most from this intervention.

Main Methods:

  • A double-blind, placebo-controlled, crossover study was conducted.
  • Children aged 1-13 with AD received either Lactobacillus rhamnosus 19070-2 and Lactobacillus reuteri DSM 122460 or placebo for 6 weeks.
  • Clinical severity (SCORAD), patient-reported outcomes, serum eosinophil cationic protein, and cytokine production were measured.

Main Results:

  • 56% of patients on probiotics reported eczema improvement versus 15% on placebo (P=.001).
  • Eczema extent decreased significantly (P=.02), while total SCORAD score did not change significantly.
  • Allergic patients showed a more pronounced treatment response, with decreased SCORAD scores (P=.02) and reduced serum eosinophil cationic protein (P=.03).

Conclusions:

  • Combination probiotic therapy with L rhamnosus and L reuteri is beneficial for managing atopic dermatitis in children.
  • The positive effects were more significant in patients with allergic profiles (positive skin prick tests, elevated IgE).
  • Further research may elucidate the precise mechanisms of probiotic action in AD.
Abstract

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