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Carmine (E-120)-induced occupational asthma revisited
Ana I Tabar-Purroy1, María J Alvarez-Puebla, Sara Acero-Sainz
1Servicio de Alergología, Hospital Virgen del Camino, CS Conde Oliveto, Plaza de la Paz SN, 31002 Pamplona, Spain.
The Journal of Allergy and Clinical Immunology
|February 18, 2003
Summary
Carmine (E-120) can cause occupational asthma (OA). In a dye factory, 41.6% were sensitized and 8.3% had OA, with higher cumulative rates when including past workers.
Area of Science:
- Occupational health
- Immunology
- Industrial hygiene
Background:
- Carmine (E-120), a natural dye, has been linked to occupational asthma (OA).
- Previous cases of carmine-induced OA were reported at this natural dye processing factory.
Purpose of the Study:
- To determine the prevalence of sensitization and OA in workers at a natural dye factory.
- To assess workers exposed to carmine, considering prior diagnoses of carmine-induced OA.
Main Methods:
- Questionnaires, skin testing (carmine, cochineal, etc.), and carmine IgE dot-blot analysis were performed on 25 workers.
- Methacholine inhalation testing and specific inhalation challenges were conducted for symptomatic individuals.
Main Results:
- Sensitization to carmine (41.7%) and cochineal (29.2%) was observed via skin tests.
- Four subjects had positive carmine IgE results; 8.3% of current workers had OA.
- Cumulative incidence of sensitization and OA reached 48.1% and 18.5% including former employees.
Conclusions:
- Carmine exposure poses a significant risk for sensitization and occupational asthma.
- Implementation of prevention programs to control airborne allergen levels is crucial.
- The findings highlight the need for monitoring and control measures in industries using carmine.
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