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Updated: Aug 15, 2026
09:03
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
[Angiogenesis research--quo vadis?]
1Abt. für Vaskläre Biologie und Angiogeneseforshcung, Klinik für Tumorbiologie Freiburg. augustin@angiogenese.de
Summary
Angiogenesis research has rapidly advanced, leading to numerous compounds in clinical trials. Despite setbacks, persistent translational research is crucial for developing effective angiomanipulatory therapies.
Area of Science:
- Biomedical research
- Vascular biology
Background:
- Angiogenesis research has surged, with publications increasing from under 200 annually in the early 1990s to over 3500 currently.
- Over 100 angiomanipulatory compounds have been identified, with more than 40 in clinical trials, reflecting significant progress in translational research.
Purpose of the Study:
- To provide an overview of the current state of angiogenesis research.
- To summarize ongoing efforts in developing angiomanipulatory therapies.
Main Methods:
- Literature review and synthesis of current research trends.
- Analysis of the progression from basic science to clinical applications.
Main Results:
- Significant growth in angiogenesis research output and identification of numerous therapeutic compounds.
- Challenges in clinical translation, evidenced by mixed outcomes in advanced trials, necessitate sustained research efforts.
Conclusions:
- The field of angiogenesis research is dynamic, with substantial basic and translational progress.
- Successful clinical implementation of angiomanipulatory therapies requires long-term commitment and endurance in translational research.
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