Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Encoding and decoding of reticulospinal commands.

Tatiana G Deliagina1, Pavel V Zelenin, Grigori N Orlovsky

  • 1Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institute, SE-171 77, Stockholm, Sweden. tatiana.deliagina@neuro.ki.se

Brain Research. Brain Research Reviews
|February 19, 2003
PubMed
Summary

The reticulospinal (RS) system in lampreys controls movement. RS neuron activity patterns dictate locomotion initiation, vigor, and turns, with spinal cord integration decoding these commands for diverse motor outputs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of CaMKIIa reticular neurons of caudal medulla in control of posture.

Communications biology·2025
Same author

Functional Organization of the Spinal Locomotor Network Based on Analysis of Interneuronal Activity.

The European journal of neuroscience·2025
Same author

Functional organization of the spinal locomotor network based on analysis of interneuronal activity.

bioRxiv : the preprint server for biology·2025
Same author

Role of CaMKIIa reticular neurons of caudal medulla in control of posture.

bioRxiv : the preprint server for biology·2025
Same author

Neuronal mechanisms underlying activation of locomotor network by epidural electrical stimulation of the spinal cord.

Experimental neurology·2025
Same author

Changes in operation of postural networks in rabbits with postural functions recovered after lateral hemisection of the spinal cord.

The Journal of physiology·2022

Area of Science:

  • Neuroscience
  • Motor Control
  • Comparative Physiology

Background:

  • The reticulospinal (RS) system is the primary descending pathway controlling spinal cord activity in lampreys.
  • Understanding how RS commands are encoded and decoded is crucial for deciphering motor control mechanisms.

Purpose of the Study:

  • To investigate the commands transmitted by the RS system to the spinal cord.
  • To elucidate the effects of these commands on spinal motor mechanisms.
  • To understand how RS signals are transformed into specific motor behaviors like locomotion and turning.

Main Methods:

  • Recording responses of RS neurons to sensory stimuli that elicit different motor behaviors.
  • Analyzing the patterns of RS neuron activation during locomotion and turning.

Related Experiment Videos

  • Utilizing a neuro-mechanical model to test hypotheses about command decoding.
  • Investigating the effects of individual RS neurons on motor output.

    • Main Results:

    • Locomotion initiation involves symmetrical, bilateral RS neuron activation; turns involve asymmetrical activation.
    • Sub-populations of RS neurons for different behaviors show partial overlap.
    • A neuro-mechanical model confirmed that RS pathway activity differences control rotation.
    • Twenty distinct patterns of RS neuron influence on motor output were identified, enabling flexion in any plane.

    Conclusions:

    • Locomotion initiation and vigor are decoded by integrating bilateral RS activity in the spinal cord.
    • Turning commands are decoded by comparing activities of specific RS neuron groups.
    • The diverse projection patterns of RS neurons allow for complex motor control, including body flexion in various planes.