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Spinal plasticity mediated by postsynaptic L-type Ca2+ channels.

Jean-François Perrier1, Aidas Alaburda, Jørn Hounsgaard

  • 1Department of Medical Physiology, Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark.

Brain Research. Brain Research Reviews
|February 19, 2003
PubMed
Summary
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L-type calcium channels in the spinal cord regulate neuron excitability through slow activation and inactivation. Metabotropic receptors fine-tune these channels, impacting neuronal networks and synaptic plasticity.

Area of Science:

  • Neuroscience
  • Cellular Electrophysiology

Background:

  • L-type calcium channels are present in spinal cord motoneurons and interneurons.
  • These channels mediate slow inward currents with minimal inactivation, contributing to neuronal excitability.

Purpose of the Study:

  • To investigate the role of L-type calcium channels in spinal cord neurons.
  • To explore the regulation of L-type calcium channel activity by metabotropic receptors.

Main Methods:

  • Electrophysiological recordings in spinal cord neurons.
  • Analysis of channel kinetics and voltage sensitivity.
  • Investigation of metabotropic receptor modulation.

Main Results:

  • L-type calcium channels exhibit slow activation and deactivation kinetics, leading to plateau potentials and bistability.

Related Experiment Videos

  • Depolarization facilitates L-type calcium channel activity.
  • Metabotropic receptors for glutamate, acetylcholine, noradrenaline, serotonin, and substance P modulate channel activity, with GABA(B) receptors causing down-regulation.

    • Conclusions:

    • Metabotropic regulation of L-type calcium channels provides flexible control over neuronal excitability and intrinsic properties.
    • This modulation influences calcium influx, suggesting a role in local synaptic plasticity.