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Related Experiment Videos

The Public Access Defibrillation (PAD) trial: study design and rationale.

Joseph P Ornato1, Mary Ann McBurnie, Graham Nichol

  • 1Department of Emergency Medicine, Medical College of Virginia, Virginia Commonwealth University Health Center, 401 North 12th Street, Box 525, Room G-248, Richmond, VA 23298-0525, USA. ornato@aol.com

Resuscitation
|February 19, 2003
PubMed
Summary

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This study investigated if lay volunteers using automated external defibrillators (AEDs) improve survival from out-of-hospital cardiac arrest (OOH-CA). Findings will inform community-based emergency response strategies.

Area of Science:

  • Emergency Medicine
  • Public Health
  • Cardiology

Background:

  • Out-of-hospital cardiac arrest (OOH-CA) has a low survival rate.
  • Community-based interventions are crucial for improving OOH-CA outcomes.
  • The role of lay responders with automated external defibrillators (AEDs) needs further investigation.

Purpose of the Study:

  • To evaluate the effectiveness of trained lay volunteers in improving survival rates for OOH-CA.
  • To assess the impact of cardiopulmonary resuscitation (CPR) alone versus CPR plus AED use by lay responders.
  • To determine the influence of lay responder interventions on neurological status, quality of life, and cost-effectiveness.

Main Methods:

  • Prospective, multicenter, randomized clinical trial involving 24 field centers in the US and Canada.

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  • Randomization of approximately 1000 community units to receive CPR alone or CPR plus AED by trained laypersons.
  • Primary endpoint: survival to hospital discharge; secondary endpoints: neurological status, HRQL, cost, and cost-effectiveness.

    • Main Results:

    • Data collection ongoing, expected completion September 2003.
    • Primary endpoint analysis focuses on survival rates to hospital discharge.
    • Secondary analyses will assess neurological outcomes, quality of life, and economic impact.

    Conclusions:

    • The PAD Trial aims to provide critical data on community-based OOH-CA management.
    • Findings will inform the integration of lay responders and AEDs into emergency medical services.
    • The study will contribute to optimizing survival and recovery for cardiac arrest victims.