Jove
Visualize
Contact Us

Related Experiment Videos

Genetics and heart disease.

Hassan Chamsi Pasha1

  • 1Department of Cardiology, King Fahd Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia. drhcpasha@hotmail.com

Saudi Medical Journal
|February 19, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Molecular Mechanisms of Diffuse Large B-Cell Lymphoma and the Complexities of Tumor Development.

Saudi medical journal·2026
Same journal

Polysomnographic and Clinical Characteristics of Narcolepsy in Saudi Arabia: <i>A 12-Year Retrospective Study</i>.

Saudi medical journal·2026
Same journal

Etiology, Management, and Outcomes of Hospitalized Heart Failure Patients: <i>A Single-Center Study</i>.

Saudi medical journal·2026
Same journal

Effect of Anesthetic Agents on Middle Ear Pressure: Systematic Review and Meta-Analysis.

Saudi medical journal·2026
Same journal

Evaluation of Raqeem Health Information System in Primary Healthcare Centers in Makkah, Saudi Arabia, Using the DeLone and McLean Information System Success Model.

Saudi medical journal·2026
Same journal

Integrating Traditional and Complementary Medicine into Saudi Primary Care: <i>A Literature Review in Light of the WHO 2025-2034 Strategy</i>.

Saudi medical journal·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Genetic factors significantly influence heart disease susceptibility and progression. Research highlights specific gene mutations linked to conditions like myocardial infarction and dilated cardiomyopathy, paving the way for advanced therapies.

Area of Science:

  • Cardiovascular Genetics
  • Genomics and Disease Etiology
  • Regenerative Medicine in Cardiology

Background:

  • Genome sequencing advances enhance understanding of disease origins.
  • Genetic predispositions to cardiovascular diseases are increasingly identified.
  • Novel therapeutic strategies are emerging for cardiac disorders.

Purpose of the Study:

  • To review current knowledge on genetic associations with cardiac diseases.
  • To highlight recent advances in understanding genetic susceptibility to myocardial infarction and other conditions.
  • To summarize emerging gene and cell-based therapies for heart failure and coronary artery disease.

Main Methods:

  • Localization of specific human genome regions associated with disease susceptibility.

Related Experiment Videos

  • Identification of gene mutations linked to cardiovascular conditions (e.g., metavinculin gene).
  • Review of studies on gene therapy, angiogenesis, and stem cell transplantation for cardiac repair.

    • Main Results:

    • A specific genome region linked to myocardial infarction susceptibility has been identified.
    • A novel apolipoprotein gene influencing triglyceride levels is described.
    • Mutations in the metavinculin gene are associated with dilated cardiomyopathy.
    • Studies demonstrate bone marrow stem cells can regenerate heart tissue post-infarction.
    • Successful autologous stem cell transplantation in cardiac infarcts has been reported.

    Conclusions:

    • Genetic factors play a crucial role in the development and progression of cardiovascular diseases.
    • Gene therapy and stem cell transplantation represent promising therapeutic avenues for managing coronary artery disease and heart failure.
    • Continued research into genetic associations will refine diagnostic and therapeutic approaches for cardiac conditions.