Related Experiment Videos
A preliminary study of baclofen-induced growth hormone release in generalised social phobia
Rita M Condren1, Jim V Lucey, Jogin H Thakore
1Neuroscience Department, St Vincent's Hospital, Richmond Road, Fairview, Dublin 3, Ireland.
Human Psychopharmacology
|February 19, 2003
Abstract
Objective:
The authors sought to examine central GABA(B) receptor responses in patients with generalised social phobia using the growth hormone (GH) response to baclofen.
Method:
Baclofen 20 mg was administered to 15 patients and 15 healthy matched controls and plasma growth hormone was monitored over a 3 h period.
Results:
The GH response in patients was significantly reduced in comparison to that of controls when calculated as both area under the curve (AUC) and delta (Delta) response.
Conclusions:
The results suggest an abnormality of central GABA(B) receptor function in this disorder.