A comparison of group sequential methods for binary longitudinal data
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Updated: Sep 27, 2026

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
Published on: September 17, 2019
Bart Spiessens1, Emmanuel Lesaffre, Geert Verbeke
1Biostatistical Center, Catholic University of Leuven, U.Z. St.-Rafaël, Kapucijnenvoer 35, B-3000 Leuven, Belgium.
Abstract:
Interim analyses are conducted to allow for early termination of the trial, for ethical as well as economical reasons. Here we consider interim analyses in repeated measurements studies where the measurements are binary. Two methods for analysing this kind of data are compared according to their operating characteristics. A subject-specific approach based on the logistic random-effects model is compared with the population-averaged approach based on the generalized estimating equations. The comparison is illustrated with simulations using a randomized clinical trial for toenail fungal infection.
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