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A novel antimicrobial peptide from the sea hare Dolabella auricularia
Ryosuke Iijima1, Jun Kisugi, Masatoshi Yamazaki
1Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Tsukui-gun, Kanagawa, Japan. ryo-iiji@pharm.teikyo-u.ac.jp
Developmental and Comparative Immunology
|February 20, 2003
Abstract:
The sea hare Dolabella auricularia is a marine shell-less gastropod. Four cytotoxic glycoproteins named dolabellanin A, C, E and P were found in the animal previously. An antimicrobial factor was newly isolated from the sea hare's body-wall including skin and mucus. This factor is a novel peptide which consists of 33 amino acid residues, and is called dolabellanin B2. Dolabellanin B2 was cytotoxically effective against some pathogenic microorganisms at a concentration of 2.5-100 microg/ml.