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Related Experiment Videos

Scanning electron microscopic and electrophoretic studies on clotting factor adsorbents.

S L Deacon, R M Howell

    Thrombosis and Haemostasis
    |August 31, 1976
    PubMed
    Summary

    Morphological and charge differences in protein and clotting factor adsorbents were identified. These physical characteristics, including surface charge and pH-mobility curves, help predict adsorbent behavior.

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    Area of Science:

    • Biochemistry
    • Materials Science
    • Surface Chemistry

    Background:

    • Protein and clotting factor adsorbents exhibit diverse physical properties.
    • Understanding these properties is crucial for predicting their interactions.

    Purpose of the Study:

    • To investigate the morphological and charge characteristics of protein and clotting factor adsorbents.
    • To correlate these physical properties with adsorbent behavior.

    Main Methods:

    • Scanning electron microscopy (SEM) for morphological analysis.
    • Electrophoretic mobility measurements to determine surface charge and pH-mobility curves.
    • Analysis of sparingly-soluble salts (calcium phosphate, barium sulfate, citrate).

    Main Results:

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    • Adsorbents were classified as amorphous or crystalline via SEM.
    • Surface charge properties varied, with some salts showing a charge reversal point in pH-mobility curves.
    • Anion type significantly influenced surface charge; phosphate and citrate ions resulted in a persistent negative potential.

    Conclusions:

    • Divalent cations with trivalent anions lead to dominant negative surface charge.
    • Physical characteristics, including morphology and electrophoretic mobility, reflect chemical composition.
    • Defined characteristics enable better prediction of adsorbent interactions with clotting factors.