Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetic gastropathy and prokinetics.

Nicholas J Talley1

  • 1Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia.

The American Journal of Gastroenterology
|February 20, 2003
PubMed
Summary

Treating diabetic gastropathy is challenging. Improving gastric emptying does not guarantee symptom relief, necessitating refined clinical trial designs for better outcomes in diabetes motility disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis.

Clinical and translational gastroenterology·2019
Same author

Effects of Psychology and Extragastrointestinal Symptoms on Health Care Use by Subjects With and Without Irritable Bowel Syndrome.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2019
Same author

Response to Zidar et al.

The American journal of gastroenterology·2019
Same author

Response to Tursi.

The American journal of gastroenterology·2019
Same author

Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Seminars in liver disease·2019
Same author

Duodenal eosinophilia is associated with functional dyspepsia and new onset gastro-oesophageal reflux disease.

Alimentary pharmacology & therapeutics·2019

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Clinical Trials

Background:

  • Diabetic gastropathy, characterized by upper GI symptoms and motility disturbances in diabetes, has suboptimal treatment outcomes.
  • The heterogeneity of diabetic gastropathy's pathophysiology complicates clinical trial design and treatment strategies.

Purpose of the Study:

  • To critically evaluate the evidence linking delayed gastric emptying to symptoms in diabetic gastropathy.
  • To review trial evidence on the efficacy of prokinetic agents for diabetic gastropathy.
  • To provide guidelines for future clinical trials in diabetic gastropathy.

Main Methods:

  • Critical evaluation of existing literature on delayed gastric emptying and symptoms.
  • Review of short- and long-term efficacy data for prokinetic agents in clinical trials.
  • Analysis of trial designs, including withdrawal designs and double-blind, parallel group studies.

Main Results:

  • Evidence suggests that improved gastric emptying does not consistently equate to symptom relief in diabetic gastropathy.
  • Current trial designs, such as withdrawal designs, may be suboptimal for evaluating treatments.
  • Validated outcome assessments and confounder measurements are crucial for future trials.

Conclusions:

  • Gastric emptying should be measured but not be the primary outcome in diabetic gastropathy trials.
  • Future trials should prioritize double-blind, parallel group designs with robust outcome measures.
  • Addressing the heterogeneous nature of diabetic gastropathy is key to developing effective treatments.

Related Experiment Videos