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Association between hepatitis C, diabetes mellitus, and race. a case-control study
Paul J Thuluvath1, Preeti R John
1Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
The American Journal of Gastroenterology
|February 20, 2003
Summary
Hepatitis C virus (HCV) cirrhosis is linked to a higher prevalence of type II diabetes mellitus (DM). This increased risk is primarily observed in Black patients with HCV infection, highlighting racial disparities in DM development.
Area of Science:
- Hepatology
- Endocrinology
- Epidemiology
Background:
- Hepatitis C virus (HCV) infection is associated with an increased prevalence of type II diabetes mellitus (DM).
- Previous studies often lacked adequate matching for key risk factors like body mass index, race, and liver disease severity.
- Understanding the specific relationship between HCV cirrhosis and DM, controlling for confounding variables, is crucial for patient management.
Purpose of the Study:
- To investigate the prevalence of type II DM in patients with HCV cirrhosis.
- To compare DM prevalence in HCV cirrhosis patients against a matched control group with cirrhosis from other causes.
- To identify risk factors for DM development in these populations, considering pre- and post-transplant status.
Main Methods:
- A case-control study was conducted involving 97 cirrhotic patients with HCV (cases) and 194 HCV-negative cirrhotic patients (controls).
- Controls were matched for age, sex, body mass index, and severity of liver disease.
- Prevalence of pre- and post-transplant type II DM was assessed in both groups.
Main Results:
- The prevalence of pretransplant DM was higher in the HCV group (19.6%) compared to controls (11.5%), though not statistically significant (p=0.06).
- Black patients with HCV exhibited a significantly higher prevalence of pretransplant DM (33.3%) compared to white patients with HCV (13.2%) and black controls (6.3%).
- Black race was identified as an independent predictor for the development of new-onset DM (OR=3.4, p=0.02), while age predicted pretransplant DM (OR=1.06, p=0.01).
Conclusions:
- The prevalence of type II DM is higher in patients with HCV cirrhosis than in matched controls with cirrhosis from other causes.
- This increased prevalence is largely attributable to a higher DM prevalence among Black patients with HCV infection.
- The findings underscore the importance of considering race in the context of HCV infection and DM risk.
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