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Influence of manganese on the release of neurotransmitters in rat striatum

A Takeda1, N Sotogaku, N Oku

  • 1Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. takedaa@u-shizuoka-ken.ac.jp

Brain Research
|February 20, 2003
PubMed

Insights

Manganese release in the brain

Area of Science:

  • Neuroscience
  • Neurochemistry

Background:

  • Evidence suggests manganese release with glutamate in the hippocampus and amygdala.
  • The role of manganese in the striatum remains less understood.

Purpose of the Study:

  • To investigate manganese release in the rat striatum.
  • To examine the influence of manganese on neurotransmitter levels in the striatum.

Main Methods:

  • In vivo microdialysis was employed in rat striatum.
  • Radioactive 54Mn was used to track manganese release.
  • Stimulation with KCl and tetrodotoxin were used to modulate release.
  • Perfusion with MnCl2 assessed neurotransmitter changes.

Main Results:

  • KCl stimulation enhanced extracellular 54Mn release in the striatum.
  • Tetrodotoxin inhibited this KCl-induced 54Mn release.
  • Perfusion with manganese chloride decreased GABA levels.
  • Glutamate, aspartate, and glycine levels were unaffected by manganese chloride.

Conclusions:

  • Manganese release in the striatum appears calcium- and impulse-dependent.
  • Manganese may influence gamma-aminobutyric acid (GABA) release in the striatum.

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