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Normal value of resting energy expenditure in healthy neonates
Wei Cai1, Lihua Yu, Changhong Lu
1Department of Pediatric Surgery, Xin Hua Hospital, Shanghai Second Medical University, Shanghai, China. aiw001@online.sh.cn
Insights
Resting energy expenditure (REE) in healthy neonates is influenced by birth weight, with higher birth weights correlating with lower REE. Predicted REE values are not suitable for clinical use in neonatal energy supplementation.
Area of Science:
- Neonatal physiology
- Metabolic research
Background:
- Accurate assessment of resting energy expenditure (REE) is crucial for neonatal nutritional support.
- Existing predictive equations for REE may not accurately reflect actual energy needs in healthy neonates.
Purpose of the Study:
- To determine the normal range of resting energy expenditure (REE) in healthy neonates.
- To identify factors influencing REE, including birth weight, sex, and delivery method.
Main Methods:
- Indirect calorimetry was used to measure REE in 180 healthy neonates.
- The study analyzed the relationship between REE and birth weight, sex, and delivery method.
Main Results:
- Birth weight significantly impacted REE, with a negative correlation observed (r = -0.289).
- Neonates weighing over 4000 g had lower REE than those weighing 2500-4000 g.
- Measured REE (48.3 +/- 6.1 kcal x kg(-1) x d(-1)) differed significantly from predicted values (54.1 +/- 1.1 kcal x kg(-1) x d(-1)).
- Sex and delivery method did not affect REE.
Conclusions:
- Predicted REE equations are inadequate for clinical neonatal energy supplementation.
- The established normal REE for healthy neonates (2500-4000 g birth weight) is 48.3 +/- 6.1 kcal x kg(-1) x d(-1).
Objective:
We investigated the value of resting energy expenditure (REE) in healthy neonates and evaluated the impact factors on REE.
Methods:
One hundred eighty healthy neonates (95 boys and 85 girls) with birth weights above 2500 g were measured by indirect calorimetry, and the effect of birth weight evaluated. Measured and predicted REEs were compared, and the effects of sex and delivery method on REE were examined in 154 newborn infants with birth weights of approximately 2500 to 4000 g.
Results:
Birth weight had a significant effect on REE. There was a negative relation between REE and birth weight (r = -0.289). The REEs of newborn infants weighing more than 4000 g were statistically lower than those of infants weighing 2500 to 4000 g (44.5 +/- 5.9 versus 48.3 +/- 6.1 kcal x kg(-1) x d(-1), P = 0.01). The measured and predicted REEs of 154 newborn infants were 48.3 +/- 6.1 and 54.1 +/- 1.1 kcal x kg(-1) x d(-1), respectively. There was a significant difference between the two values. Sex and delivery methods had no effect on REE in healthy neonates.
Conclusions:
The value from the predicted equation is not suitable for neonatal energy supplementation in clinical practice. The normal REE value for healthy neonates with birth weights of 2500 to 4000 g is 48.3 +/- 6.1 kcal x kg(-1) x d(-1).