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[Pemphigoid gestationis: a study of 15 cases]
S Boudaya1, H Turki, T J Meziou
1Service de Dermatologie, CHU Hédi-Chaker, 3029 Sfax, Tunisie.
Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|February 20, 2003
Summary
Pemphigoid gestationis is a rare pregnancy dermatosis. This study profiles its epidemiology, clinical features, and treatment, noting dapsone
Area of Science:
- Dermatology
- Immunodermatology
- Obstetrics
Context:
- Pemphigoid gestationis (PG) is a rare subepidermal bullous dermatosis.
- Typically occurs in the second or third trimester of pregnancy or postpartum.
- Often affects women with previous pregnancies.
Purpose:
- To profile the epidemiology, clinical aspects, treatment, and evolution of pemphigoid gestationis.
- To analyze a hospital series of 15 confirmed cases.
Summary:
- The study included 15 patients with PG, with onset between 19-39 years (mean 30).
- Most cases (73%) occurred in multigravida women, presenting in the last trimester.
- Pruritus followed by an erythematous maculopapular eruption was common; diagnosis confirmed by direct immunofluorescence (C3 linear band).
- Systemic corticosteroids were used in 54%, dapsone in 26%, and antihistamines/topical steroids in 20%.
- Recurrence was observed postpartum in 53.3% and in subsequent pregnancies in two patients.
Impact:
- The findings align with literature regarding late pregnancy onset, multigravida frequency, and lack of newborn involvement.
- Highlights facial involvement and the efficacy of dapsone as particularities of PG.
- Provides insights into managing this rare pregnancy-related dermatosis.