Related Experiment Video
Updated: Sep 27, 2026

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting
Published on: August 4, 2023
Metoclopramide pretreatment attenuates emergency contraceptive-associated nausea
Ronald E Ragan1, Randall W Rock, Henry W Buck
1Department of Pharmacy Practice, University of Kansas School of Pharmacy, Lawrence 66045, USA. ragan@ku.edu
Objective:
The study was undertaken to determine whether metoclopramide pretreatment attenuates side effects associated with high-dose estrogen/progestin emergency contraception in at-risk patients.
Study Design:
This was a randomized, prospective, double-blind, placebo-controlled study at the University of Kansas. Patients (141) requesting emergency contraception and lacking contraindications were offered entry in the study. Both the treatment (metoclopramide 10 mg) and placebo groups received active emergency contraception. Participants evaluated symptom severity with a 12-question survey tool developed for this study.
Results:
Metoclopramide pretreatment provided protection against nausea and cramping associated with estrogen/progestin emergency contraception. The average scores on a 10-point scale for the treatment group and placebo group were as follows: nausea 3.2 versus 4.8 (P =.01) and cramping 0.9 versus 2.2 (P <.01), indicating less severe nausea and cramping in the treatment group.
Conclusion:
Metoclopramide pretreatment attenuates the nausea and cramping associated with Yuzpe emergency contraceptive treatment.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
Drugs for Treatment of Constipation-Predominant IBS
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists