Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationship of constitutional factors and cigarette smoking to decrease in 1-second forced expiratory volume.

C E Barter, A H Campbell

    The American Review of Respiratory Disease
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Immediate impact of whole-body vibration on backward walking in individuals with Parkinson disease.

    Physiotherapy theory and practice·2025
    Same author

    27 years of benthic and coral community dynamics on turbid, highly urbanised reefs off Singapore.

    Scientific reports·2016
    Same author

    Flow-volume curve changes in patients with obstructive sleep apnoea and brief upper airway dysfunction.

    Respirology (Carlton, Vic.)·2000
    Same author

    Total head excursion and resting head posture: normal and patient comparisons.

    Archives of physical medicine and rehabilitation·2000
    Same author

    The prevalence of obstructive sleep apnea in hypertensives.

    American journal of respiratory and critical care medicine·1998
    Same author

    Exertional oxygen of limited benefit in patients with chronic obstructive pulmonary disease and mild hypoxemia.

    American journal of respiratory and critical care medicine·1995
    Same journal

    Human lung lysozyme: sources and properties.

    The American review of respiratory disease·2015
    Same journal

    "Immotile-cilia" syndrome and ciliary abnormalities induced by infection and injury.

    The American review of respiratory disease·2013
    Same journal

    Adult criteria for obstructive apnea do not identify children with serious obstruction.

    The American review of respiratory disease·1993
    Same journal

    Cell adhesion molecules and the bronchial epithelium.

    The American review of respiratory disease·1993
    Same journal

    Adhesion molecules and cytokine production.

    The American review of respiratory disease·1993
    Same journal

    Molecular mechanisms mediating lymphocyte recirculation, inflammation, and metastasis formation.

    The American review of respiratory disease·1993
    See all related articles

    Individual susceptibility, not just smoking, significantly impacts chronic bronchitis progression. Factors like bronchial reactivity and sputum eosinophilia predict lung function decline in mild chronic bronchitis patients.

    Area of Science:

    • Pulmonology
    • Respiratory Medicine
    • Clinical Research

    Background:

    • Chronic bronchitis is characterized by progressive lung function decline.
    • Individual variability in disease progression is significant but not fully understood.
    • Identifying factors beyond smoking is crucial for managing chronic bronchitis.

    Purpose of the Study:

    • To investigate individual variations in the annual rate of forced expiratory volume in 1 second (FEV1) decrease in mild chronic bronchitis.
    • To identify host susceptibility factors contributing to this variation.
    • To explore the interaction between smoking and host susceptibility in disease progression.

    Main Methods:

    • A 5-year prospective survey of 34 subjects with mild chronic bronchitis.
    • Measurement of annual decrease in forced expiratory volume in 1 second (FEV1).

    Related Experiment Videos

  • Assessment of bronchial reactivity to methacholine, ventilatory responsiveness to isoproterenol, and sputum eosinophilia as indicators of host susceptibility.

    • Main Results:

    • Marked individual variation in annual FEV1 decline was observed (mean decrease: 0.046 L/year).
    • Smokers showed a greater mean annual FEV1 decrease (0.056 L/year) than non- and ex-smokers (0.016 L/year).
    • Host susceptibility factors, including bronchial reactivity to methacholine (r=0.76), ventilatory responsiveness to isoproterenol (r=0.45), and sputum eosinophilia, significantly correlated with FEV1 decline.
    • Minimal smoking combined with high methacholine reactivity led to severe ventilatory deterioration.

    Conclusions:

    • Individual host susceptibility plays a critical role in the progression of chronic bronchitis, independent of smoking levels.
    • Bronchial hyperreactivity, ventilatory responsiveness, and sputum eosinophilia are key indicators of susceptibility.
    • The interaction between smoking and host susceptibility determines the rate of lung function deterioration.