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Computed tomography-guided core needle biopsy for bone and soft tissue tumors
Josephine Issakov1, Gideon Flusser, Yehuda Kollender
1Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. JIssakov2000@yahoo.com
The Israel Medical Association Journal : IMAJ
|February 21, 2003
Summary
Computed tomography-guided core needle biopsy (CT-guided CNB) is a safe and effective method for diagnosing bone and soft tissue tumors. This study found CT-guided CNB achieved 90% diagnostic accuracy in musculoskeletal lesions.
Area of Science:
- Orthopedic oncology
- Musculoskeletal pathology
- Diagnostic imaging
Background:
- Imaging-guided core needle biopsy (CNB) is standard for diagnosing bone and soft tissue lesions in specialized centers.
- Computed tomography (CT) guidance offers a precise approach for these biopsies.
Purpose of the Study:
- To evaluate the accuracy of CT-guided core needle biopsy for musculoskeletal lesions.
- To present diagnostic results from a specialized orthopedic oncology center.
Main Methods:
- 215 CT-guided core needle biopsies were performed on bone (135) and soft tissue (80) lesions between 1998 and 2000.
- Biopsies were conducted by a single radiologist and examined by a single pathologist.
- Diagnostic accuracy was assessed by comparing biopsy results with definitive surgical diagnoses.
Main Results:
- CT-guided CNB demonstrated 90% diagnostic accuracy for musculoskeletal lesions.
- Malignancy was identified in 89 bone lesions and 35 soft tissue lesions.
- Only three cases initially diagnosed as benign were later found to be malignant; no significant complications occurred.
Conclusions:
- CT-guided CNB is a safe and effective procedure for obtaining adequate histologic material from musculoskeletal tumors.
- The technique provides high diagnostic accuracy (90%) and rapid processing, with reliable immunostaining.
- Optimal tumor sampling, including diverse directions and necrotic areas, is crucial, particularly for soft tissue sarcomas.