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Updated: Aug 19, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Prevalence of cardiovascular risk factors before kidney transplantation
Muriel Rice1, Judy Martin, Donna Hathaway
1University of Tennessee Health Science Center, Memphis, Tenn., USA.
Insights
Higher BMI and cholesterol levels were observed in kidney transplant recipients who experienced cardiovascular events post-transplant. Diabetes and a family history of cardiovascular disease were also more prevalent in this group.
Area of Science:
- Nephrology
- Cardiology
- Transplantation
Background:
- Cardiovascular risk factor assessment is crucial for kidney transplant recipients.
- Individualized interventions can reduce cardiovascular morbidity and mortality.
Purpose of the Study:
- To examine the prevalence of pretransplant cardiovascular risk factors.
- Focus on modifiable, potentially modifiable, and nonmodifiable factors.
- Study period: January 1, 1994, to December 31, 1996.
Main Methods:
- Retrospective nested case-control design.
- Compared kidney transplant recipients with (n=12) and without (n=66) posttransplant cardiovascular events.
- Data analyzed using frequencies, t tests, and chi-squared analyses.
Main Results:
- Patients with cardiovascular events had higher mean BMI (>25 kg/m2) and serum total cholesterol (>200 mg/dL).
- Diabetes was more prevalent (33%) in patients with cardiovascular events.
- These patients were predominantly African American men with a higher prevalence of cardiovascular disease history.
Conclusions:
- Pretransplant cardiovascular risk factors significantly differ between kidney transplant recipients with and without posttransplant events.
- Identifying these factors can inform targeted interventions.
- Further research into specific risk factor management is warranted.
Context:
Assessing the prevalence of cardiovascular risk factors is an essential step in developing risk profiles and individualizing interventions to reduce the cardiovascular morbidity and mortality of kidney transplant recipients.
Objective:
To examine the prevalence of pretransplant modifiable, potentially modifiable, and nonmodifiable cardiovascular risk factors in patients who received kidney transplants between January 1, 1994, and December 31, 1996.
Design:
An exploratory, retrospective nested case-control design was employed to assess pretransplant cardiovascular risk factors in kidney transplant recipients with documented posttransplant cardiovascular events (n = 12) and kidney transplant recipients with no documented posttransplant cardiovascular events (n = 66). Data were analyzed using frequencies, unpaired t tests, and chi 2 analyses.
Results:
Significantly higher means of body mass index values greater than 25 kg/m2 (32.3 +/- 5.8 kg/m2 vs 28.8 +/- 3.4 kg/m2) and serum total cholesterol levels greater than 200 mg/dL (254.5 +/- 5.7 mg/dL vs 242.3 +/- 39.3 mg/dL) were noted in patients with documented cardiovascular events compared to those with no documented cardiovascular events, respectively. Diabetes was more prevalent in patients with documented cardiovascular events (33%); these patients were also predominantly African American men who had a higher prevalence of family and personal histories of cardiovascular disease (17% and 33%).
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