Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apolipoprotein E polymorphism and atherosclerosis.

Genovefa Kolovou1, Deliana Daskalova, Dimitri P Mikhailidis

  • 1Cardiology Department, Onassis Cardiac Surgery Centre, Athens, Greece.

Angiology
|February 21, 2003
PubMed
Summary

The apolipoprotein E (apo E) genotype

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of fibrate treatment in dyslipidemia: an overview.

Current pharmaceutical design·2013
Same author

Hydrochlorothiazide vs. chlorthalidone as the optimal diuretic for the management of hypertension.

Current pharmaceutical design·2013
Same author

PCSK9 inhibition - a novel mechanism to treat lipid disorders?

Current pharmaceutical design·2013
Same author

Combined dyslipidemia: should the focus be LDL cholesterol or atherogenic dyslipidemia?

Current pharmaceutical design·2013
Same author

Achieving current goals in prevention and treatment of vascular disease: an update.

Current pharmaceutical design·2013
Same author

Pioglitazone and cancer: angel or demon?

Current pharmaceutical design·2013

Area of Science:

  • Cardiovascular Research
  • Genetics
  • Biochemistry

Background:

  • The link between apolipoprotein E (apo E) and vascular disease is complex and not fully understood.
  • Contradictory findings in research are attributed to variations in ethnicity, age, gender, diagnostic criteria, and environmental factors.
  • Interactions between apo E genotypes, other genes, and vascular risk factors further complicate the relationship.

Purpose of the Study:

  • To review the current understanding of the apolipoprotein E (apo E) and vascular disease relationship.
  • To explore the potential clinical applications of apo E genotyping in managing vascular disease.
  • To identify the challenges and future research directions for apo E genotyping in clinical practice.

Main Methods:

  • Literature review of studies investigating apolipoprotein E (apo E) and vascular disease.
  • Analysis of factors contributing to inconsistent research findings.
  • Discussion of potential clinical utility and future research needs.

Main Results:

  • The relationship between apolipoprotein E (apo E) and vascular disease remains poorly defined due to numerous confounding factors.
  • Apo E genotyping may predict drug treatment response or risk of vascular death (e.g., myocardial infarction, stroke).
  • Further research is needed to establish apo E genotyping's role in vascular disease management.

Conclusions:

  • Apolipoprotein E (apo E) genotyping requires rapid, cost-effective, and simple methods for widespread clinical relevance.
  • The clinical utility of apo E genotyping in vascular disease management needs further investigation.
  • Future applications may focus on predicting acute ischemic events or treatment responses rather than general disease risk.

Related Experiment Videos