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Updated: Aug 13, 2026

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
Published on: January 19, 2019
Sib 1893 possesses pro- and anticonvulsant activity in the electroshock seizure threshold test in mice
Jarogniew Luszczki1, Kinga K Borowicz, Stanisław J Czuczwar
1Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland.
Abstract:
SIB 1893, a non-competitive antagonist of group I metabotropic glutamate receptor subtype 5, administered at the doses ranging between 0.5-2 mg/kg markedly lowered the electroconvulsive threshold, whereas if applied at the higher dose of 40 mg/kg, it significantly raised the threshold for electroconvulsions in mice, exhibiting both pro- and anticonvulsive properties in this test.
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