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Related Experiment Videos

Covert bacteriuria in nephrotic syndrome.

U S Rai1, Uday Kumar, Hemant Kumar

  • 1Department of Nephrology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna.

Indian Journal of Pathology & Microbiology
|February 21, 2003
PubMed
Summary

Covert bacteriuria affects 18.53% of nephrotic syndrome patients undergoing kidney biopsy. This urinary tract infection is linked to lower serum albumin and higher protein excretion.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Urology

Background:

  • Nephrotic syndrome is a kidney disorder characterized by heavy proteinuria, edema, and low serum albumin.
  • Covert bacteriuria, the presence of bacteria in urine without symptoms, can complicate various medical conditions.
  • Kidney biopsy is a crucial diagnostic tool for nephrotic syndrome, offering insights into underlying pathology.

Purpose of the Study:

  • To determine the prevalence of covert bacteriuria in patients with nephrotic syndrome admitted for kidney biopsy.
  • To identify common uropathogens and associated clinical and histopathological findings in bacteriuric patients.

Main Methods:

  • A cross-sectional study was conducted on 205 patients undergoing kidney biopsy for nephrotic syndrome.
  • Urine cultures were performed to detect bacteriuria.

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  • Serum albumin levels and 24-hour urinary protein excretion were measured.
  • Histopathological findings from kidney biopsies were analyzed.

    • Main Results:

    • Covert bacteriuria was detected in 18.53% (38/205) of patients.
    • Escherichia coli was the most frequent pathogen, identified in 78.9% of bacteriuric cases.
    • Bacteriuric patients exhibited significantly lower serum albumin and higher 24-hour urinary protein excretion compared to abacteriuric individuals.
    • Membranous nephropathy was the most common histopathological finding (39.47%) among bacteriuric patients.

    Conclusions:

    • Covert bacteriuria is a significant finding in nephrotic syndrome patients undergoing kidney biopsy.
    • The presence of bacteriuria correlates with poorer biochemical markers and specific kidney pathologies.
    • Further investigation into screening and management strategies for covert bacteriuria in this population is warranted.