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Related Experiment Videos

Nanosizing: a formulation approach for poorly-water-soluble compounds.

Elaine Merisko-Liversidge1, Gary G Liversidge, Eugene R Cooper

  • 1Elan Drug Delivery, 3500 Horizon Dr, King of Prussia, PA 19406, USA. elaine.liversidge@elan.com

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|February 21, 2003
PubMed
Summary

Media milling technology transforms poorly-water-soluble drugs into nanocrystalline particles, overcoming formulation challenges. This NanoCrystal Technology enables stable drug delivery across various administration routes and product types.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Poorly water-soluble compounds present significant challenges in drug development.
  • Conventional formulation methods often lead to early abandonment of promising drug candidates.

Purpose of the Study:

  • To introduce and evaluate media milling technology for formulating poorly water-soluble drugs.
  • To demonstrate the potential of NanoCrystal Technology in improving drug product development.

Main Methods:

  • Utilizing media milling (attrition process) to reduce large drug crystals to nanometer-sized particles.
  • Employing a water-based stabilizer solution during the milling process to create stable dispersions.
  • Generating nanocrystalline particles (NCPs).

Main Results:

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  • Physically stable dispersions of nanometer-sized drug crystals were successfully generated.
  • Nanocrystalline particles proved suitable for oral, injectable (IV, SC, IM), and topical administration.
  • Aqueous dispersions of nanoparticles were amenable to post-processing into various dosage forms (tablets, capsules, lyophilized products).

Conclusions:

  • NanoCrystal Technology effectively addresses formulation deficiencies of poorly water-soluble drugs.
  • The technology supports all stages of drug development, from discovery to marketed product enhancement.
  • Nanocrystalline particles offer a versatile drug delivery system with broad applicability.