Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Validation of an image analysis method for estimating coating thickness on pellets.

Crilles C Larsen1, Jørn M Sonnergaard, Poul Bertelsen

  • 1Pharmaceutical Research and Development, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark. Crilles@Crilles.dk

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|February 21, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets.

Journal of pharmaceutical sciences·2022
Same author

Intranasal treatment of cluster headache: A response.

Headache·2022
Same author

Intranasal ketamine for acute cluster headache attacks-Results from a proof-of-concept open-label trial.

Headache·2021
Same author

Ockham's Razor Applied on Pharmaceutical Powder Compaction Models.

Journal of pharmaceutical sciences·2020
Same author

Viscosupplementation may preserve tibial cartilage and collagen in osteoarthritis: findings from a preclinical model of osteoarthritis.

Journal of experimental orthopaedics·2020
Same author

Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2016

This study validates a digital image analysis method for accurately measuring pellet size and coating thickness using optical microscopy. The method demonstrates excellent precision and robustness, crucial for pharmaceutical quality control.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Analytical Chemistry

Background:

  • Accurate measurement of pellet size and coating thickness is critical in pharmaceutical manufacturing for drug delivery and efficacy.
  • Traditional methods can be time-consuming and may lack precision.

Purpose of the Study:

  • To evaluate a digital image analysis method for estimating mean pellet size and coating thickness.
  • To assess the repeatability, intermediate precision, and robustness of this image analysis technique.

Main Methods:

  • Optical microscopy coupled with digital image analysis.
  • Calculation of coating thickness based on the difference in projected area radius of uncoated and coated pellets.
  • Investigation of method performance under varying conditions.

Related Experiment Videos

Main Results:

  • The image analysis method exhibited excellent repeatability and intermediate precision with minimal measurement scatter.
  • Robustness testing highlighted the critical importance of controlled illumination and equipment calibration.
  • An accuracy of +/-1.2 micrometers was achieved using 1000 pellets with high sphericity and narrow size distribution.

Conclusions:

  • Digital image analysis provides a reliable and precise method for determining pellet size and coating thickness.
  • Strict control over illumination and regular calibration are essential for method accuracy.
  • A predictive equation is provided for determining the sample size needed for desired accuracy.