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Production of macrosphelide A by the mycoparasite Coniothyrium minitans
Mark P McQuilken1, Jacqueline Gemmell, Robert A Hill
1Department of Plant Biology, Scottish Agricultural College, Ayr Campus, Auchincruive Estate, KA6 5HW, Ayr, UK. m.mcquilken@au.sac.ac.uk
FEMS Microbiology Letters
|February 21, 2003
Abstract:
Coniothyrium minitans, a mycoparasite of sclerotia of Sclerotinia sclerotiorum and Sclerotium cepivorum, produced four closely related metabolites inhibitory to fungal growth. The major metabolite, identified as macrosphelide A, had IG(50) values (the concentration of metabolite to inhibit growth by 50%) of 46.6 and 2.9 microgram ml(-1) against S. sclerotiorum and S. cepivorum, respectively. This is the first report of both antifungal activity due to macrosphelide A as well as isolation of macrosphelide A from C. minitans.