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Propofol 1% versus propofol 2% in children undergoing minor ENT surgery

M Pellégrini1, C Lysakowski, L Dumont

  • 1Division of Anaesthesiology, Department of Anaesthesiology, Geneva University Hospitals, Geneva, Switzerland. michel.pellegrini@hcuge.ch

British Journal of Anaesthesia
|February 21, 2003
PubMed

Insights

Propofol 1% and 2% demonstrate similar efficacy for inducing anesthesia in pediatric patients undergoing ENT surgery. Both concentrations offer comparable safety profiles and intubating conditions, making them suitable alternatives.

Area of Science:

  • Anesthesiology
  • Pediatric Anesthesia
  • Pharmacology

Background:

  • Investigated induction characteristics of propofol 1% versus 2% in pediatric patients.
  • Study focused on children undergoing otolaryngology (ENT) surgery.
  • Employed a prospective, randomized, double-blind design for robust comparison.

Purpose of the Study:

  • To compare the induction properties of propofol 1% and 2% in children.
  • To evaluate safety and efficacy for anesthesia induction in pediatric ENT surgery.

Main Methods:

  • 108 children received either propofol 1% (n=55) or 2% (n=53) for anesthesia induction and maintenance.
  • Propofol was administered at 4 mg/kg at a constant rate (1200 ml/h), supplemented with alfentanil.
  • Intubating conditions were assessed without neuromuscular blocking agents.

Main Results:

  • Propofol 2% showed a more rapid loss of consciousness (47s vs. 54s; P=0.02).
  • Pain on injection was slightly higher with propofol 2% (21% vs. 9%), though not statistically significant (P=0.09).
  • No significant differences were observed in spontaneous movements, intubating conditions, hemodynamic changes, or adverse events.

Conclusions:

  • Propofol 1% and 2% exhibit comparable performance for anesthesia induction in pediatric ENT surgery.
  • Both concentrations provide satisfactory intubating conditions and similar safety profiles.
  • The choice between propofol 1% and 2% may not significantly impact outcomes for this patient group.
Abstract

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