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Relation of urinary total hydroxyproline: Creatinine ratio to height velocity in children with retarded growth

S Edwards, M Martog, C A Pennock

    Archives of Disease in Childhood
    |February 1, 1976
    PubMed

    Insights

    The hydroxyproline-to-creatinine ratio in urine cannot reliably predict height velocity in children with small stature. This biomarker is likely only useful for monitoring individual children during short-term therapy.

    Area of Science:

    • Pediatric Endocrinology
    • Biochemical Markers
    • Growth and Development

    Background:

    • Small stature in children can have various underlying causes.
    • Accurate assessment of growth velocity is crucial for diagnosis and management.
    • Biochemical markers are explored to aid in growth assessment.

    Purpose of the Study:

    • To evaluate the utility of the urinary total hydroxyproline:creatinine ratio in predicting height velocity.
    • To determine if this ratio can reliably predict growth in children with small stature.

    Main Methods:

    • Collected random urine samples from 18 boys and 11 girls with small stature.
    • Excluded children with significant growth hormone deficiency.
    • Monitored growth and development over one year.

    Main Results:

    • The hydroxyproline:creatinine ratio prediction of height velocity was incorrect in 35% of cases.
    • The study found the ratio to be unreliable for predicting overall height growth.

    Conclusions:

    • The urinary total hydroxyproline:creatinine ratio is not a reliable predictor of height velocity in children with small stature.
    • Its primary utility may be in monitoring individual patient responses during short-term therapeutic interventions.

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