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Related Experiment Videos

In vivo multiple-mouse imaging at 1.5 T.

S Xu1, T P F Gade, C Matei

  • 1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.

Magnetic Resonance in Medicine
|February 21, 2003
PubMed
Summary
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A novel multiple-mouse MRI coil enables simultaneous in vivo imaging of up to 13 mice. This tool effectively screens for tumors, accurately measuring their size for preclinical research.

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Preclinical Research

Background:

  • Developing efficient methods for in vivo tumor screening in mice is crucial for drug development and cancer research.
  • Existing MRI techniques can be time-consuming for screening large cohorts of animals.

Purpose of the Study:

  • To develop and evaluate a multiple-mouse solenoidal MR coil for simultaneous in vivo imaging of up to 13 mice.
  • To assess the coil's effectiveness in detecting and measuring orthotopic tumors (>2 mm) within a practical timeframe (<1 hour magnet time).

Main Methods:

  • A multiple-mouse solenoidal MR coil was designed for a 1.5 T clinical scanner.
  • Spin echo sequences were employed to acquire magnetic resonance images (MRIs).
  • Image resolution was assessed, and tumor sizes measured via MRI were correlated with histopathology.

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Main Results:

  • The coil achieved moderate-to-high resolution images (156-176 µm in-plane, 1.5 mm slice thickness).
  • Primary brain tumors in transgenic mice and orthotopic xenografts were successfully detected.
  • MRI-measured brain tumor size strongly correlated with histopathology (P < 0.001).
  • Metastatic lung tumors were also imaged effectively in a screening context.

Conclusions:

  • The developed multiple-mouse MR coil is a sensitive and effective tool for in vivo tumor screening in mice.
  • It allows for accurate tumor size measurement and can be implemented on standard clinical scanners with minimal modifications.
  • This coil significantly enhances the efficiency of preclinical cancer research by enabling simultaneous imaging of multiple subjects.