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Prevention of mucosally induced uveitis with a HSP60-derived peptide linked to cholera toxin B subunit
Paula A Phipps1, Miles R Stanford, Jia-Bin Sun
1Peter Gorer Department of Immunobiology, Guy's, King's and St. Thomas' School of Medicine and Dentistry, Guy's Hospital, London,GB.
Abstract:
Oral administration of the uveitogenic peptide (aa 336-351) derived from human HSP60 induced clinical and histological manifestations of uveitis in 65.8% (48/73) of Lewis rats. Uveitis was significantly decreased to 16.7% (11/66) in parallel experiments with the peptide linked to recombinant cholera toxin B subunit (rCTB), also given by mouth (chi(2)=34.2, p<0.0001). The protective efficacy between tolerized and immunized animals was 74.7%. Adoptive transfer of mesenteric lymph node cells from tolerized rats prevented the development of uveitis. A significantly higher proportion of regulatory CD4(+)CD45RC(low)RT6(+) subset of Th2 memory cells were found in the mesenteric lymph nodes (p<0.005) and spleens (p
