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Related Experiment Videos

Apparent diffusion coefficient: a quantitative parameter for in vivo tumor characterization.

Andreas M Herneth1, Samira Guccione, Mark Bednarski

  • 1Department of Radiology, Division of Muskulo Skeletal Radiology, University of Vienna, AKH-7F Währinger Gürtel 18-20, A-1090 Vienna, Austria. andreas.herneth@univie.ac.at

European Journal of Radiology
|February 22, 2003
PubMed
Summary
This summary is machine-generated.

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Diffusion weighted imaging (DWI) can non-invasively monitor tumor progression by tracking changes in apparent diffusion coefficient (ADC). Increased ADC values in tumors indicate tissue structural changes, correlating with necrosis and aiding in diagnosis.

Area of Science:

  • Biomedical Imaging
  • Oncology
  • Radiology

Background:

  • Tumor progression involves complex changes in tissue microstructure.
  • Accurate characterization of these changes is crucial for effective cancer management.
  • Non-invasive imaging techniques are needed to monitor tumor development and heterogeneity.

Purpose of the Study:

  • To evaluate the potential of diffusion weighted imaging (DWI) to differentiate tissue compartments in early, intermediate, and advanced tumor stages.
  • To assess the correlation between apparent diffusion coefficient (ADC) values and tumor progression.
  • To explore DWI as a diagnostic tool for in-vivo tissue characterization.

Main Methods:

  • Squamous cell tumor (SCCVII) was induced in 22 male mice.
  • Mice underwent MRI scanning using a clinical 1.5 T scanner, including DWI, T1-SE, T2-FSE, and contrast-enhanced T1-SE sequences.

Related Experiment Videos

  • Apparent diffusion coefficient (ADC) was calculated for different tumor compartments using a pixel-by-pixel method, followed by histopathological correlation.

    • Main Results:

    • Early-stage tumors showed homogeneous diffusion patterns with a mean ADC of 0.64±0.06 x 10⁻³ mm²/s.
    • ADC values increased significantly in tumor rim areas with progression (intermediate: 0.70±0.11; advanced: 0.88±0.11; necrosis: 1.03±0.06 x 10⁻³ mm²/s).
    • Increased ADC correlated with areas of necrosis (reduced cell density) on histology, while ADC in viable tumor remained constant.

    Conclusions:

    • Apparent diffusion coefficient (ADC) derived from DWI provides a non-invasive method to monitor changes in tumor tissue structure during progression.
    • DWI demonstrates potential as a diagnostic tool for in-vivo tissue characterization of tumors.
    • This technique can help distinguish between viable tumor and necrotic areas, aiding in treatment assessment.